DNA Origami Detects Proteins

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Modular DNA origami

Phys Org

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Science

DNA origami suggests route to reusable, multifunctional biosensors

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Scientists at Caltech have developed a technique called DNA origami to create a lilypad-like structure tethered by a DNA linker to a gold electrode.

When the analyte binds to those short DNA strands, the structure gets pulled down to the gold surface, bringing 70 reporter molecules into contact with the surface.

The relatively large size of the structure also means that the system can readily accommodate and detect larger molecules, such as large proteins.

The team hopes the system might also be useful for proteomics.

"Within a few hours , you could measure hundreds of proteins using a single system," Guareschi says.

"You could do a wash, switch the analytes, and remeasure several times," he says.

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